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Suberosin

CAT: 0804-HY-N1196-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1196-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].
CAS Number
581-31-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/suberosin.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC(C/C=C(C)\C)=C(OC)C=C2O1
Molecular Formula
C15H16O3
Molecular Weight
244.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.|[2]Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52 (10) :1335-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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