SK-575
CAT:
804-HY-139156-05
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SK-575
- CAS Number: 2523016-96-6
- UNSPSC Description: SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations[1].
- Target Antigen: PARP; PROTACs
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sk-575.html
- Smiles: O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCCCCCCCCC(N4CCN(C(C5=CC(CC6=NNC(C7=C6C=CC=C7)=O)=CC=C5F)=O)CC4)=O
- Molecular Weight: 876.97
- References & Citations: [1]Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.
- Shipping Conditions: Blue Ice