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Recombinant Human Galectin-3

CAT: 0355-AP60483Size: InquireDry Ice: NoHazardous: No
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Background
Human Galectin-3 also named AGE-R3, CBP35, GAL3, L29, LGALS3, Mac-2, is belonging to the galectins family and it is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22. It is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides. Given Galectin-3’s broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and Ventricular remodeling. Human Galectin-3 shares 79% amino acid sequence identity with rat and mouse Galectin-3, respectively.
Product Name Alternative
AGE-R3, CBP35, GAL3, L29, LGALS3, Mac-2
Gene ID
3958
UniProt
P17931
Target
ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYPGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSATGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI
Purification
> 98 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 0.1 EU/ug of rHuGalectin-3 as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The ED50 as determined by its ability to agglutinate human red blood cells is less than 10 μg/ml.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 26.0 kDa, a single non-glycosylated polypeptide chain containing 249 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered solution in 1xPBS, 5% Trehalose, 0.02% Tween-20, 3mM β-ME, pH 7.4.
Host or Source
Escherichia coli

UniProtKB · P17931

Galectin-3

LEG3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17931
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LGALS3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Gal-3
EC number
—
Processing
—
Secondary accessions
B2RC38, Q16005, Q6IBA7, Q96J47
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondPhosphoprotein

Cellular component

CytoplasmNucleusSecretedSpliceosome

Biological process

DifferentiationImmunityInnate immunitymRNA processingmRNA splicing

Molecular function

IgE-binding protein

Ligand

Lectin

Domain

Repeat

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