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4-Methyldaphnetin

CAT: 0804-HY-N4286-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4286-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].
CAS Number
2107-77-9
UNSPSC
12352005
Hazard Statement
H319, H334
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-methyldaphnetin.html
Purity
99.40
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1C=C(C)C2=CC=C(O)C(O)=C2O1
Molecular Formula
C10H8O4
Molecular Weight
192.17
Precautions
H319, H334
References & Citations
[1]Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21 (Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86 (2) :210-21.|[2]Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27 (3) :268-74.|[3]Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7 (9) :2091-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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