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Jaspamycin

CAT: 0804-HY-111759-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111759-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].
CAS Number
22242-96-2
Product Name Alternative
7-CN-7-C-Ino
UNSPSC
12352005
Target
Parasite; PKA
Type
Reference compound
Related Pathways
Anti-infection; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Jaspamycin.html
Purity
98.94
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2C#N)N=CN1
Molecular Formula
C12H12N4O5
Molecular Weight
292.25
References & Citations
[1]Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10 (1) :1421.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKA; PKAR; Trypanosoma

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