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Emrusolmin

CAT: 0804-HY-101855-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101855-01Size:5 mg
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Description
Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn) . Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology[1][2].
CAS Number
882697-00-9
Product Name Alternative
Anle138b
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/emrusolmin.html
Purity
99.93
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
BrC1=CC(C2=CC(C3=CC=C(OCO4)C4=C3)=NN2)=CC=C1
Molecular Formula
C16H11BrN2O2
Molecular Weight
343.17
Precautions
H315, H319, H335
References & Citations
[1]Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125 (6) :795-813.|[2]Martinez Hernandez A, et al. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Mol Med. 2018;10 (1) :32-47.|[3]Heras-Garvin A, et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2019;34 (2) :255-263.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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A20001-200Emrusolmin (Anle138b) 200mg
A20001-25Emrusolmin (Anle138b) 25mg
A20001-10mM-DEmrusolmin (Anle138b) 10mM * 1mL in DMSO

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