Stiripentol

• Description :

  Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively.

• Product Name Alternative :

  BCX2600

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Cytochrome P450

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Stiripentol.html

• Purity :

  99.99

• Solubility :

  DMSO : 150 mg/mL (ultrasonic; warming)

• Smiles :

  CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1

• Molecular Formula :

  C14H18O3

• Molecular Weight :

  234.29

• Precautions :

  H302

• References & Citations :

  [1]Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34 (4) :608-11. Epub 2006 Jan 13.|[2]Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53 (7) :1140-5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  CYP2; CYP3

• CAS Number :

  [49763-96-4]