Stiripentol

CAT: 0804-HY-103392-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103392-01Size:5 mg

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Description

Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively.

CAS Number

49763-96-4

Product Name Alternative

BCX2600

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Stiripentol.html

Purity

99.99

Solubility

DMSO : 150 mg/mL (ultrasonic; warming)

Smiles

CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1

Molecular Formula

C14H18O3

Molecular Weight

234.29

Precautions

H302

References & Citations

[1]Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34 (4) :608-11. Epub 2006 Jan 13.|[2]Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53 (7) :1140-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

CYP2; CYP3

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