(Thr4,Gly7)-Oxytocin

(Thr4,Gly7)-Oxytocin

• CAS Number: 60786-59-6
• UNSPSC Description: (Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].
• Target Antigen: Oxytocin Receptor; Potassium Channel
• Type: Peptides
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/thr4-gly7-oxytocin.html
• Purity: 99.90
• Solubility: DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL
• Smiles: O=C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N1)=O)N)C(NCC(N[C@@H](CC(C)C)C(NCC(N)=O)=O)=O)=O)=O)CC(N)=O)=O)([H])[C@H](O)C)=O)([H])[C@@H](C)CC)[C@@H]1CC2=CC=C(C=C2)O
• Molecular Weight: 940.10
• References & Citations: [1]Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. |[2]Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. |[3]M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported