O-1602

O-1602

• CAS Number: 317321-41-8
• UNSPSC Description: O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1[1].
• Target Antigen: GPR55
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/o-1602.html
• Purity: 99.79
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC1=C([C@H]2[C@@H](CCC(C)=C2)C(C)=C)C(O)=CC(O)=C1
• Molecular Weight: 258.36
• References & Citations: [1]Jinlong Zhang, et al. GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal.Heliyon, 10 (2024), e30462.|[2]A. Díaz-Arteaga,et al. The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats. Diabetes, Obesity and Metabolism. March 2012, Volume14, Issue3.|[3]Peng Ma,et al. IAVPGEVA: Orally Available DPP4-Targeting Soy Glycinin Derived Octapeptide with Therapeutic Potential in Nonalcoholic Steatohepatitis.Journal of Agricultural and Food Chemistry. 2024, 72, 13, 7167–7178.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C
• Clinical Information: No Development Reported