CASP4 Polyclonal Antibody

• Background:

  This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

• Abbreviation:

  CASP4

• UniProt:

  P49662

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Recombinant Human CASP4 protein expressed by E.coli

• Target:

  Apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; CASP4; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE (rel) -II; ICE (rel) II; ICEREL II; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC; IF

• Field of Research:

  Cancer; Cell Biology; Metabolism

• Purification:

  Antigen Affinity Purification

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:400-1:800; IF 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG