Products for Research Use Only
RegisterLogin

MBCQ

CAT: 0804-HY-114672-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-114672-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM) . MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE[1][2][3].
CAS Number
150450-53-6
Product Name Alternative
SMP 114
UNSPSC
12352005
Hazard Statement
H413
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mbcq.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC2=C(N=CN=C2NCC3=CC4=C(C=C3)OCO4)C=C1
Molecular Formula
C16H12ClN3O2
Molecular Weight
313.74
Precautions
H413
References & Citations
[1]Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37 (13) :2106-11.|[2]Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317 (1) :188-95.|[3]Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39 (3) :47-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE2; PDE3; PDE4; PDE5

Related Products

CatalogName
HY-107093-01MBC-11
HY-107093AMBC-11 (trisodium)
HY-107093BMBC-11 (triethylamine)

Alternative Products

CatalogName
MBS5764824MBCQ

Popular Products