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Sacituzumab

CAT: 0804-HY-P99045-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99045-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan. Sacituzumab govitecan can be used in the field of triple-negative breast cancer[1][2][3][4].
CAS Number
1796566-95-4
Product Name Alternative
HRS7
UNSPSC
12352203
Target
ADC Antibody; TROP2
Type
Inhibitory Antibodies
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sacituzumab.html
Purity
99.86
Solubility
H2O
Smiles
[Sacituzumab]
Molecular Weight
(145.52 kDa)
References & Citations
[1]Bardia A, et al. Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer. Ann Oncol. 2021 Sep;32 (9) :1148-1156.|[2]Zhou DD, et al. Elucidating the development, characterization, and antitumor potential of a novel humanized antibody against Trop2[J]. Int J Biol Macromol. 2023 Dec 31;253 (Pt 6) :127105.|[3]Sun M, et al. Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2[J]. iScience. 2021 Sep 30;24 (10) :103190. |[4]Shih LB, et al. In vitro and in vivo reactivity of an internalizing antibody, RS7, with human breast cancer[J]. Cancer Res. 1995 Dec 1;55 (23 Suppl) :5857s-5863s.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 4

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