SC912

CAT: 0804-HY-161409-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-161409-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SC912 is an AR-V7 inhibitor (IC50 = 0.36 μM) . SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis[1].

UNSPSC

12352005

Target

Androgen Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sc912.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=CC(NC(NC2=CC=C(C(F)(F)F)C=C2NC(C3=CC(Cl)=CC(Cl)=C3)=O)=O)=C1

Molecular Formula

C22H13Cl2F3N4O2

Molecular Weight

493.27

References & Citations

[1]Qianhui Y et al. SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal domain Oncogene. 2024 Mar

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

SC912

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