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4-PQBH

CAT: 0804-HY-115901-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115901-01Size:5 mg
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Description
4-PQBH is a potent Nur77 binder (KD=1.17 μM) . 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].
CAS Number
2243355-51-1
Product Name Alternative
CNS 1102 (free base)
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A; Paraptosis
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-pqbh.html
Concentration
10mM
Purity
99.14
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CC=NC=C1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2
Molecular Formula
C22H17N5O
Molecular Weight
367.40
References & Citations
[1]Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1

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