4-PQBH

• Description :

  4-PQBH is a potent Nur77 binder (KD=1.17 μM) . 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].

• CAS Number :

  [2243355-51-1]

• Product Name Alternative :

  CNS 1102 (free base)

• UNSPSC :

  12352005

• Target :

  Nuclear Hormone Receptor 4A/NR4A; Paraptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/4-pqbh.html

• Concentration :

  10mM

• Purity :

  99.14

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(N/N=C/C1=CC=NC=C1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2

• Molecular Formula :

  C22H17N5O

• Molecular Weight :

  367.40

• References & Citations :

  [1]Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Nur77/NR4A1