ZYZ-488

• Description :

  ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3[1].

• UNSPSC :

  12352005

• Target :

  Caspase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/zyz-488.html

• Purity :

  99.94

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

• Smiles :

  O=C(OCCCCNC(N)=N)C(C=C1OC)=CC(OC)=C1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2

• Molecular Formula :

  C20H29N3O11

• Molecular Weight :

  487.46

• References & Citations :

  [1]Wang Y, et al. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1470302-79-4]