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Monotropein

CAT: 0804-HY-N0648-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0648-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS) -induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin -induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury[1][2][3].
CAS Number
5945-50-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/monotropein.html
Purity
99.09
Solubility
H2O : 31.25 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(O)CO)([H])[C@@](C=C3)([H])C(C(O)=O)=CO2
Molecular Formula
C16H22O11
Molecular Weight
390.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang F, et al.Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes.Int Immunopharmacol. 2014 Dec;23 (2) :575-80.|[2]Zhang, Y., et al., (2020) . The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 129, 110408.|[3]Gong, Y., & Wang, J. (2023) . Monotropein alleviates sepsis-elicited acute lung injury via the NF-κB pathway. The Journal of pharmacy and pharmacology, 75 (9), 1249–1258.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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