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Serum thymic factor

CAT: 0804-HY-P3206-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3206-01Size:5 mg
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Description
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine -induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases[1][2][3][4].
CAS Number
63958-90-7
Product Name Alternative
Thymulin; Thymic factor
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
ERK
Type
Peptides
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/serum-thymic-factor.html
Purity
98.09
Solubility
10 mM in DMSO
Smiles
NC(C[C@@H](C(O)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C33H54N12O15
Molecular Weight
858.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Dardenne M, et al. Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci. 2006 Nov;1088:153-63.|[2]Mizutani M, et al. In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice. Arch Virol. 1996;141 (1) :73-83.|[3]Kohda Y, et al. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Nov;28 (11) :2087-91.|[4]Pardo J, et al. Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin[J]. Physiological Mini Reviews (PMR), 2012, 6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Nonathymulin

Nonathymulin is a small molecule drug. Nonathymulin has a monoisotopic molecular weight of 858.38 Da.

CAS Number63958-90-7
PubChem CID3085284
IUPAC Name(2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
Molecular FormulaC33H54N12O15
Molecular Weight858.9
XLogP-10.9
Topological Polar Surface Area452
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count16
Rotatable Bond Count28
Heavy Atom Count60
Formal Charge0
Complexity1610
SMILES
C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H]1CCC(=O)N1
InChI
InChI=1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1
InChIKey
LIFNDDBLJFPEAN-BPSSIEEOSA-N
Chemical Structure
2D Structure
2D structure of Nonathymulin
CAS: 63958-90-7
CID: 3085284
Formula: C33H54N12O15
MW: 858.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight858.9
XLogP3-10.9
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count16
Rotatable Bond Count28
Exact Mass858.38315906
Monoisotopic Mass858.38315906
Topological Polar Surface Area452 Ų
Heavy Atom Count60
Formal Charge0
Complexity1610
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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