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Anti-Pan-GRK

CAT: 1303-75-179Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-179Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
G protein-coupled receptor (GPCR) kinases (GRKs), are important regulators of GPCR function and mediate receptor desensitization, internalization, and signaling. Several non-GPCR proteins also serve as GRK substrates, and GRKs have been shown to have kinase-independent functions through regulation of receptors and effectors. These proteins are members of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. GRKs phosphorylate activated forms of G protein-coupled receptors to regulate their signaling.
Description
Our Anti-Pan-GRK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N145/20. It detects human, mouse, and rat Pan-GRK, and is purified by Protein A chromatography. It is great for use in ICC, WB.
Short Description
Our Anti-Pan-GRK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N145/20. It detects human, mouse, and rat Pan-GRK, and is purified by protein a chromatography. It is great for use in WB, ICC, ELISA.
Synonyms
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene Name
Grk5 Gprk5 Grk6 Gprk6
UniProt
Q8VEB1
Host
Mouse
Reactivity
Human, Mouse, and Rat
Immunogen
Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (accession number Q8VEB1) produced recombinantly in E. Coli
Target
Pan-GRK
Clonality
Monoclonal
Isotype
IgG1
Clone
N145/20
Type
Primary Antibody
Applications
WB, ICC, ELISA
Field of Research
Cell Signaling/G Protein Signaling
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.107
Molecular Weight
70 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Specificity
Cross-reacts with GRK6
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Mouse
WB Brain Quality Control
1
Conjugate
Unconjugated
RRID
AB_2232788

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