(±) -Silybin

• Description :

  (±) -Silybin is the racemate of Silybin (HY-N0779A) . Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

• Product Name Alternative :

  Silibinin (mixture of Silybin A and Silybin B)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/racemic-silybin.html

• Purity :

  99.40

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC[C@@H]1[C@@H](C2=CC(OC)=C(C=C2)O)OC3=CC([C@H]4OC5=CC(O)=CC(O)=C5C([C@@H]4O)=O)=CC=C3O1

• Molecular Formula :

  C25H22O10

• Molecular Weight :

  482.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20 (9) :2190.|[2]Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [36804-17-8]