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Nesvacumab

CAT: 0804-HY-P99036-01Size: 1 mgDry Ice: YesHazardous: No
CAT#:0804-HY-P99036-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches[1][2].
CAS Number
[1296818-77-3]
UNSPSC
12352203
Target
Tie
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/nesvacumab.html
Purity
99.11
Solubility
H2O
Smiles
[Nesvacumab]
Molecular Weight
(144.86 kDa)
References & Citations
[1]Kyriakos P Papadopoulos, et al. A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2016 Mar 15;22 (6) :1348-55.|[2]Vakili S, et al. Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature. Aging Cell. 2025 Feb;24 (2) :e14375.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1

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