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Anti-CASK Antibody

CAT: 1303-75-000Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-000Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Calcium/Calmodulin-Dependent Serine Protein Kinase or CASK scaffolding protein is encoded by the gene CASK. CASK is a member of the MAGUK (membrane-associated guanylate kinase) protein family. CASK is a a calcium/calmodulin-dependent serine protein kinase. CASK is found in many different tissues including kidney, lung, liver and brain. In the brain, CASK protein is located at synapses. CASK acts as a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Mutations in this gene are associated with FG syndrome 4, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability.
Description
Our Anti-CASK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K56A/50. It is KO validated, detects chicken, human, mouse, rat, Xenopus, and zebrafish CASK, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Short Description
Our Anti-CASK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K56A/50. It is KO validated, detects chicken, human, mouse, rat, xenopus, and zebrafish CASK, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.
Synonyms
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene Name
CASK LIN2
UniProt
O14936
Host
Mouse
Reactivity
Chicken, Human, Mouse, Rat, Xenopus, and Zebrafish
Immunogen
Fusion protein amino acids 318-415 of rat CASK/Lin2 (accession number Q62915) produced recombinantly in E. Coli
Target
CASK
Clonality
Monoclonal
Isotype
IgG1
Clone
K56A/50
Type
Primary Antibody
Applications
WB, IHC, ICC, IP, ELISA
Field of Research
Scaffold Proteins
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
Molecular Weight
100 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
IHC Dilution
1:500
WB Dilution
1:1000
Specificity
No cross-reactivity reported
ICC Dilution
1:500
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Human
WB Brain Quality Control
1
Conjugate
Unconjugated
RRID
AB_2068730

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