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APY0201

CAT: 0804-HY-15982-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15982-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns (3,5) P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production.
CAS Number
1232221-74-7
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Interleukin Related; PIKfyve
Type
Reference compound
Related Pathways
Immunology/Inflammation; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/APY0201.html
Concentration
10mM
Purity
99.42
Solubility
DMSO : ≥ 35 mg/mL
Smiles
CC1=CC(/C=N/NC2=NC3=CC(C4=CC=NC=C4)=NN3C(N5CCOCC5)=C2)=CC=C1
Molecular Formula
C23H23N7O
Molecular Weight
413.48
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Hayakawa N, et al. Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201. Bioorg Med Chem. 2014 Jun 1;22 (11) :3021-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-12; IL-23

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