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Anti-MESD Antibody

CAT: 1303-75-129Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-129Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mesoderm Development LRP Chaperone is encoded by the gene MESD. MESD is a member of the MESD family. MESD is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) . MESD acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESD is essential for the specification of embryonic polarity and mesoderm induction. MESD plays an essential role neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. MESD is expressed in many tissues, but not in skeletal muscles. Diseases associated with MESD include Osteogenesis Imperfecta, Type Xx and Epilepsy, Nocturnal Frontal Lobe, 2.
Description
Our Anti-MESD mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N88/12. It detects human, mouse, and rat MESD, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Short Description
Our Anti-MESD mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N88/12. It detects human, mouse, and rat MESD, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, IP, ELISA.
Synonyms
LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)
Gene Name
Mesd Mesdc2
UniProt
Q9ERE7
Host
Mouse
Reactivity
Human, Mouse, and Rat
Immunogen
Fusion protein amino acids 30-95 and 118-180 (lacking VSD domain) of mouse MESD (accession number Q9ERE7) produced recombinantly in E. Coli
Target
MESD
Clonality
Monoclonal
Isotype
IgG2b
Clone
N88/12
Type
Primary Antibody
Applications
WB, IHC, ICC, IP, ELISA
Field of Research
Cell Signaling/Wnt Signaling
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.56
Molecular Weight
26 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Specificity
No cross-reactivity reported
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Mouse
WB Brain Quality Control
1
Conjugate
Unconjugated
RRID
AB_2143727

UniProtKB · Q9ERE7

LRP chaperone MESD

MESD_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9ERE7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mesd
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8C611, Q8CCX7, Q91WK8, Q9CVB9
Protein keywords

Technical term

3D-structureReference proteome

Molecular function

Chaperone

Cellular component

Endoplasmic reticulum

PTM

Glycoprotein

Domain

Signal

Biological process

Wnt signaling pathway

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GTR17936936MESD Antibody
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