Hydroxocobalamin

• Description:

  Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B12 deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease[1][2][3][4][5][6].

• Product Name Alternative:

  Vitamin B12a

• UNSPSC:

  12352300

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hydroxocobalamin.html

• Purity:

  99.32

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[N]([Co+3]34([N]5=C[N@@]([C@@H](O[C@H](CO)[C@H]6OP7([O-])=O)[C@@H]6O)C8=C5C=C(C)C(C)=C8)([OH-])[N-]9C2[C@H](CC(N)=O)[C@@](C)(CCC(NC[C@H](C)O7)=O)C9=C(C)C([C@@H](CCC(N)=O)C%10(C)C)=[N]3C%10=CC%11=[N]4C([C@](CC(N)=O)(C)[C@@H]%11CCC(N)=O)=C%12C)=C%12[C@@H](CCC(N)=O)[C@]1(C)CC(N)=O

• Molecular Formula:

  C62H89CoN13O15P

• Molecular Weight:

  1346.36

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Thompson JP, et al. Hydroxocobalamin in cyanide poisoning. Clin Toxicol (Phila) . 2012;50 (10) :875-885.|[2]Paredes RM, et al. Comparison of hydroxocobalamin with other resuscitative fluids in volume-controlled and uncontrolled hemorrhage models in swine (Sus-scrofa) . J Trauma Acute Care Surg. 2023;95 (2S Suppl 1) :S120-S128.|[3]Olivieri G, et al. Improved biochemical and neurodevelopmental profiles with high-dose hydroxocobalamin therapy in cobalamin C defect. J Inherit Metab Dis. 2025;48 (1) :e12787.|[4]Dépret F, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23 (1) :421. Published 2019 Dec 23.|[5]Bruins Slot, et al. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology. 1997 Aug;113 (2) :430-3.|[6]Shepherd G, et al. Role of hydroxocobalamin in acute cyanide poisoning. Ann Pharmacother. 2008;42 (5) :661-669.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  J Clin Transl Hepatol. 2024 Jul 28;12 (7) :625-633.|Nat Commun. 2021 Nov 22;12 (1) :6786.|Nat Commun. 2025 Jan 31;16 (1) :1233.

• CAS Number:

  13422-51-0