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ML327

CAT: 0804-HY-103038-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103038-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT) .
CAS Number
1883510-31-3
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; c-Myc
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML327.html
Purity
98.02
Solubility
DMSO : 32 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=CNC1=O)NCCCNC(C2=NOC(C3=CC=CC=C3)=C2)=O
Molecular Formula
C19H18N4O4
Molecular Weight
366.37
Precautions
H302
References & Citations
[1]Rellinger EJ, et al. Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma. Oncotarget. 2017 Jul 20;8 (53) :91040-91051.|[2]An H, et al. Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition.Oncotarget. 2015 Sep 8;6 (26) :22934-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(3-(2-hydroxynicotinamido)propyl)-5-phenylisoxazole-3-carboxamide
CAS Number1883510-31-3
PubChem CID60167648
IUPAC NameN-[3-[(2-oxo-1H-pyridine-3-carbonyl)amino]propyl]-5-phenyl-1,2-oxazole-3-carboxamide
Molecular FormulaC19H18N4O4
Molecular Weight366.4
XLogP2
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity625
SMILES
C1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCNC(=O)C3=CC=CNC3=O
InChI
InChI=1S/C19H18N4O4/c24-17-14(8-4-9-20-17)18(25)21-10-5-11-22-19(26)15-12-16(27-23-15)13-6-2-1-3-7-13/h1-4,6-9,12H,5,10-11H2,(H,20,24)(H,21,25)(H,22,26)
InChIKey
NNNDNXLMQAPQQQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(2-hydroxynicotinamido)propyl)-5-phenylisoxazole-3-carboxamide
CAS: 1883510-31-3
CID: 60167648
Formula: C19H18N4O4
MW: 366.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.4
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass366.13280507
Monoisotopic Mass366.13280507
Topological Polar Surface Area113 Ų
Heavy Atom Count27
Formal Charge0
Complexity625
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA3368-5.1ML327
A17009-100ML327 100mg
A17009-5ML327 5mg
A17009-50ML327 50mg
A17009-25ML327 25mg
A17009-10ML327 10mg

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