DOTATATE (acetate)

• Description:

  DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1][2][3][4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319

• Target:

  Radionuclide-Drug Conjugates (RDCs)

• Type:

  Peptides

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dotatate-acetate.html

• Purity:

  99.95

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC (O) =O.O=C ([C@@H] (NC ([C@H] (CSSC[C@H] (NC ([C@] (NC ([C@@H] (NC1=O) CCCCN) =O) ([H]) [C@H] (O) C) =O) C (N[C@H] (C (O) =O) [C@H] (O) C) =O) NC ([C@H] (NC (CN2CCN (CCN (CCN (CC2) CC (O) =O) CC (O) =O) CC (O) =O) =O) CC3=CC=CC=C3) =O) =O) CC4=CC=C (C=C4) O) N[C@@H]1CC5=CNC6=CC=CC=C56.[x]

• Molecular Formula:

  C65H90N14O19S2.xC2H4O2

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S.|[2]Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10.|[3]Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30 (6) :917-20.|[4]Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27 (3) :273-82.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 4

• Isoform:

  RDC Peptide

• CAS Number:

  177943-89-4