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Foscarnet (sodium)

CAT: 0804-HY-B1318-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1318-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
CAS Number
63585-09-1
Product Name Alternative
Trisodium phosphonoformate; Phosphonoformic acid trisodium salt
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/foscarnet-sodium.html
Concentration
10mM
Purity
98.0
Solubility
H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(O[Na])(O[Na])C(O[Na])=O
Molecular Formula
CNa3O5P
Molecular Weight
191.95
Precautions
H302, H315, H319, H335
References & Citations
[1]Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34 (2) :373-5.|[2]Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium) .Pharmacol Ther. 1982;19 (3) :387-415.|[3]Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Foscarnet Sodium

Trisodium phosphonoformate is the trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as an antiviral drug. It is an organic sodium salt and a one-carbon compound. It contains a phosphonatoformate.

CAS Number63585-09-1
PubChem CID44561
IUPAC Nametrisodium;phosphonatoformate
Molecular FormulaCNa3O5P
Molecular Weight191.95
Topological Polar Surface Area103
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count10
Formal Charge0
Complexity103
SMILES
C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]
InChI
InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3
InChIKey
DFHAXXVZCFXGOQ-UHFFFAOYSA-K
Chemical Structure
2D Structure
2D structure of Foscarnet Sodium
CAS: 63585-09-1
CID: 44561
Formula: CNa3O5P
MW: 191.95
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight191.95
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass191.91764294
Monoisotopic Mass191.91764294
Topological Polar Surface Area103 Ų
Heavy Atom Count10
Formal Charge0
Complexity103
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count4
Compound Is CanonicalizedYes

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