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Sweroside

CAT: 0804-HY-N0806-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0806-01Size:1 mg
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Description
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields[1][2][3][4].
CAS Number
14215-86-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Apoptosis; Autophagy; Keap1-Nrf2; NF-κB; NOD-like Receptor (NLR) ; PARP; Pyroptosis; Sirtuin
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sweroside.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
C=C[C@@H]1[C@@](CCOC2=O)([H])C2=CO[C@H]1O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO
Molecular Formula
C16H22O9
Molecular Weight
358.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Li J, et al. Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis. Front Cardiovasc Med. 2021 Mar 19;8:650368.|[2]Han XL, et al. Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis. Biomed Pharmacother. 2017 Nov;95:477-486.|[3]Wang J, et al. Anti-inflammatory Effects of Sweroside on LPS-Induced ALI in Mice Via Activating SIRT1. Inflammation. 2021 Oct;44 (5) :1961-1968.|[4]Ding Y, et al. Sweroside alleviates hepatic steatosis in part by activating AMPK/mTOR-mediated autophagy in mice. J Cell Biochem. 2023 Jul;124 (7) :1012-1022.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NLRP3; SIRT1

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