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BNN6

CAT: 0804-HY-164117-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164117-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT) [1][2][3].
CAS Number
106476-75-9
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bnn6.html
Purity
98.0
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=NN(C(C)CC)C1=CC=C(N(C(C)CC)N=O)C=C1
Molecular Formula
C14H22N4O2
Molecular Weight
278.35
References & Citations
[1]Jiang M, et al., BiTiS3 bio-transducer with explosive on-demand generation of NO gas for synergetic cancer therapy. Biosens Bioelectron. 2024 Feb 15;246:115895.|[2]Yang J, et al. Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel. Int J Nanomedicine. 2024 Nov 8;19:11499-11516.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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