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UNC0224

CAT: 0804-HY-10929-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10929-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1][2].
CAS Number
[1197196-48-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UNC0224.html
Purity
98.85
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CN1CCC(NC2=C3C=C(OC)C(OCCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1
Molecular Formula
C26H43N7O2
Molecular Weight
485.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52 (24) :7950-3.|[2]Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53 (15) :5844-57.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C

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Alternative Products

CatalogName
M10700-01UNC0224
TBI5216-1MGUNC0224, G9a histone methyl transferase inhibitor
217435HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7- (3-Dimethylaminopropoxy) -6-methoxy-2- (4-methyl-1,4-diazepan-1-yl) -N- (1-methylpiperidin-4-yl) quinazolin-4-amine, H2O)

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