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Meleagrin

CAT: 0804-HY-N6797Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6797Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].
CAS Number
71751-77-4
UNSPSC
12352005
Target
Antibiotic; Bacterial; c-Met/HGFR
Type
Natural Products
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/meleagrin.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(O)C(N3/C1=C/C5=CN=CN5)=O
Molecular Formula
C23H23N5O4
Molecular Weight
433.46
References & Citations
[1]Newmister SA, et al. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosyntheticpathway. Org Biomol Chem. 2018 Sep 11;16 (35) :6450-6459.|[2]Zheng CJ, et al. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action. PLoS One. 2013 Nov 28;8 (11) :e78922.|[3]Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15;24 (2) :113-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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