Meleagrin

• Description:

  Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial; c-Met/HGFR

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/meleagrin.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N[C@@]23N (OC) C4=C (C=CC=C4) [C@]2 (C (C) (C) C=C) C=C (O) C (N3/C1=C/C5=CN=CN5) =O

• Molecular Formula:

  C23H23N5O4

• Molecular Weight:

  433.46

• References & Citations:

  [1]Newmister SA, et al. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosyntheticpathway. Org Biomol Chem. 2018 Sep 11;16 (35) :6450-6459.|[2]Zheng CJ, et al. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action. PLoS One. 2013 Nov 28;8 (11) :e78922.|[3]Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15;24 (2) :113-22.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  71751-77-4