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Physalaemin

CAT: 0804-HY-P0255-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0255-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
CAS Number
2507-24-6
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Physalaemin.html
Solubility
10 mM in H2O
Smiles
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]3N(CCC3)C([C@H](CC(O)=O)NC([C@H](C)NC([C@H]4NC(CC4)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C58H84N14O16S
Molecular Weight
1265.44
References & Citations
[1]Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96 (3) :252-9.|[2]Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo) . 2006 Jun;54 (6) :827-31.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NK1R

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PPY-4030Physalaemin
T19518L-01Physalaemin acetate
PE-55393-01Physalaemin Peptide

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