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Nyasol

CAT: 0804-HY-138050-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138050-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nyasol ((-) -Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS -stimulated BV-2 microglial cells[1][2].
CAS Number
96895-25-9
Product Name Alternative
(-) -Nyasol; (Z) -Hinokiresinol; cis-Hinokiresinol
UNSPSC
12352005
Target
Bacterial; Fungal; Leukotriene Receptor; NO Synthase; Parasite
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nyasol.html
Solubility
10 mM in DMSO
Smiles
C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2
Molecular Formula
C17H16O2
Molecular Weight
252.31
References & Citations
[1]Lim H, et al. (-) -Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32 (11) :1509-14.|[2]Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66 (5) :435-8.|[3]Lee HJ, et al. (-) -Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28 (5) :954-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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