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Trivalent hydroxyarsinothricn

CAT: 0804-HY-158378Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158378Size:1 Each
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Description
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy[1].
Product Name Alternative
R-AST-OH
UNSPSC
12352211
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trivalent-hydroxyarsinothricn.html
Smiles
O=C(O)[C@H](N)CC[As](O)O
Molecular Formula
C4H10AsNO4
Molecular Weight
211.05
References & Citations
[1]Sarkarai Nadar V, et al. Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4- (dihydroxyarsinoyl) Butanoate. Organometallics. 2024 May 8;43 (10) :1137-1142.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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