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Remetinostat

CAT: 0804-HY-100365-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100365-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Remetinostat (SHP-141) is a hydroxamic acid-based histone deacetylase (HDAC) inhibitor. Remetinostat alleviates Imiquimod -induced psoriatic dermatitis. Remetinostat can be used for study of cutaneous T-cell lymphoma[1][2].
CAS Number
946150-57-8
Product Name Alternative
SHP-141
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Remetinostat.html
Purity
98.0
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=CC=C(OC(CCCCCCC(NO)=O)=O)C=C1
Molecular Formula
C16H21NO6
Molecular Weight
323.34
Precautions
H228, H315, H319
References & Citations
[1]Yijun Deng, et al. Process Development of the Soft Histone Deacetylate Enzyme Inhibitor SHP-141: Acylation of Methyl Paraben and Suberyl Hydroxamic Acid Formation. Org. Process Res. Dev. 2016, 20, 10, 1812-1820.|[2]Jin L, et al. Topical histone deacetylase inhibitor remetinostat improves IMQ-induced psoriatic dermatitis via suppressing dendritic cell maturation and keratinocyte differentiation and inflammation. Eur J Pharmacol. 2024 Nov 15;983:177011.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA4141-10Remetinostat
A12149-10Remetinostat 10mg
A12149-50Remetinostat 50mg
A12149-25Remetinostat 25mg
A12149-200Remetinostat 200mg
A12149-100Remetinostat 100mg
A12149-5Remetinostat 5mg
A12149-10mM-DRemetinostat 10mM * 1mL in DMSO

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