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NSC15520

CAT: 0804-HY-138155-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138155-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA) . NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1].
CAS Number
730960-98-2
UNSPSC
12352211
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc15520.html
Purity
99.90
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
C[C@@]1(C(O)=O)CCC[C@]2(C)[C@]3([H])[C@]4(C(C(O)=O)[C@H]([C@@H](C3)C(C(C)C)=C4)C(O)=O)CC[C@@]12[H]
Molecular Formula
C24H34O6
Molecular Weight
418.52
References & Citations
[1]Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19 (8) :2589-95.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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