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KPLH1130

CAT: 0804-HY-128578-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128578-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ( + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions[1].
CAS Number
906669-07-6
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Interleukin Related; NO Synthase; PDHK
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kplh1130.html
Purity
99.86
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NNC(N2C3=CC=C(C)C=C3)=O)C(O)=C1
Molecular Formula
C15H13N3O3
Molecular Weight
283.28
References & Citations
[1]Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-(2,4-dihydroxyphenyl)-4-(4-methylphenyl)-1H-1,2,4-triazol-5-one
CAS Number906669-07-6
PubChem CID135487465
IUPAC Name3-(2,4-dihydroxyphenyl)-4-(4-methylphenyl)-1H-1,2,4-triazol-5-one
Molecular FormulaC15H13N3O3
Molecular Weight283.28
XLogP2.2
Topological Polar Surface Area85.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity432
SMILES
CC1=CC=C(C=C1)N2C(=NNC2=O)C3=C(C=C(C=C3)O)O
InChI
InChI=1S/C15H13N3O3/c1-9-2-4-10(5-3-9)18-14(16-17-15(18)21)12-7-6-11(19)8-13(12)20/h2-8,19-20H,1H3,(H,17,21)
InChIKey
UUTBMTOBGXJTLN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2,4-dihydroxyphenyl)-4-(4-methylphenyl)-1H-1,2,4-triazol-5-one
CAS: 906669-07-6
CID: 135487465
Formula: C15H13N3O3
MW: 283.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight283.28
XLogP32.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass283.09569129
Monoisotopic Mass283.09569129
Topological Polar Surface Area85.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8073-5.1KPLH1130
A18494-25KPLH1130 25mg
A18494-5KPLH1130 5mg
A18494-100KPLH1130 100mg
A18494-10KPLH1130 10mg
A18494-50KPLH1130 50mg
A18494-500KPLH1130 500mg
A18494-1KPLH1130 1mg
A18494-10mM-DKPLH1130 10mM * 1mL in DMSO

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