KIF18A-IN-2

KIF18A-IN-2

• CAS Number: 2600559-20-2
• UNSPSC Description: KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer[1].
• Target Antigen: Kinesin; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kif18a-in-2.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
• Molecular Weight: 534.69
• References & Citations: [1]Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported