2-Deoxy-2-fluoro-L-fucose

• Product Name Alternative:

  Adonitol-5-13C; Adonite-5-13C, Adonitol-3-13C; Adonite-3-13C

• UNSPSC Description:

  2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-deoxy-2-fluoro-l-fucose.html

• Purity:

  99.99

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C[C@@H](F)[C@@H]([C@@H]([C@H](C)O)O)O

• Molecular Weight:

  166.15

• References & Citations:

  [1]Herrera H, et al. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019;20(10):2528. Published 2019 May 23.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  70763-62-1