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Ricolinostat

CAT: 0804-HY-16026-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16026-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50s of 58, 48, and 51 nM, respectively.
CAS Number
1316214-52-4
Product Name Alternative
ACY-1215; Rocilinostat
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ACY-1215.html
Purity
99.83
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CN=C(N(C2=CC=CC=C2)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
Molecular Formula
C24H27N5O3
Molecular Weight
433.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Santo L, et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with PS-341 in multiple myeloma. Blood. 2012 Mar 15;119 (11) :2579-89.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8

Alternative Products

CatalogName
BUP15489-01Ricolinostat
C13112-1gRicolinostat (ACY-1215)

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