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FR901464

CAT: 0804-HY-16212-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16212-01Size:1 mg
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Description
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].
CAS Number
146478-72-0
UNSPSC
12352005
Hazard Statement
H315, H319, H351
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fr901464.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H](O1)/C=C/C(C)=C/C[C@H](O[C@@H]2C)[C@H](C[C@H]2NC(/C=C\[C@H](C)OC(C)=O)=O)C)[C@@]3(C[C@]1(O)C)CO3
Molecular Formula
C27H41NO8
Molecular Weight
507.62
Precautions
H315, H319, H351
References & Citations
[1]H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo) . 1996 Dec;49 (12) :1204-11.|[2]Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79 (12) :5697-709.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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