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XL44

CAT: 0804-HY-162393-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162393-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins[1].
CAS Number
2637949-91-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xl44.html
Purity
98.00
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(OC)C=C1)NC2=CC=CC(/C=C3C(NC4=C\3C=C(F)C=C4)=O)=C2
Molecular Formula
C23H17FN2O3
Molecular Weight
388.39
References & Citations
[1]Xiuxiu Lu, et al. A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins. Nat Commun. 2024 Mar 20;15 (1) :2485.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA3203-50XL44

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