INCB3619

• Description :

  INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity[1].

• CAS Number :

  [791826-72-7]

• UNSPSC :

  12352005

• Target :

  Apoptosis; MMP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/incb3619.html

• Purity :

  99.46

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N([C@H](C(N1CC=C(C2=CC=CC=C2)CC1)=O)[C@@H](C(NO)=O)C3)CC43CC4)OC

• Molecular Formula :

  C22H27N3O5

• Molecular Weight :

  413.47

• References & Citations :

  [1]Bin-Bing S Zhou, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006 Jul;10 (1) :39-50.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported