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UNC10201652

CAT: 0804-HY-148044-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148044-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC10201652 is a potent Loop 1 (L1) -specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].
CAS Number
372495-52-8
UNSPSC
12352005
Target
Bacterial; β-glucuronidase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/unc10201652.html
Purity
99.33
Solubility
DMSO : 13.3 mg/mL (ultrasonic; warming)
Smiles
C1(N=NN=C2N3CCNCC3)=C2SC4=C1C(CCCC5)=C5C(N6CCOCC6)=N4
Molecular Formula
C20H25N7OS
Molecular Weight
411.52
References & Citations
[1]Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15 (1) :217-225.|[2]Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4 (7) :868-879.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA1388-25UNC10201652

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