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Barlerin

CAT: 0804-HY-N0758-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0758-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB.
CAS Number
57420-46-9
Product Name Alternative
8-O-Acetyl shanzhiside methyl ester
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Caspase; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8-O-Acetyl_shanzhiside_methyl_ester.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(C)OC(C)=O)([H])[C@@]([C@H](O)C3)([H])C(C(OC)=O)=CO2
Molecular Formula
C19H28O12
Molecular Weight
448.42
Precautions
H302, H315, H319
References & Citations
[1]Zhang L, et al. 8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats. Basic Clin Pharmacol Toxicol. 2014 Dec;115 (6) :481-7.|[2]Kang ZC, et al. Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. Eur J Pharm Sci. 2012 Aug 30;47 (1) :124-30.|[3]Jiang WL, et al. Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke. Basic Clin Pharmacol Toxicol. 2011 Jan;108 (1) :21-7.|[4]Fan PC, et al. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. J Ethnopharmacol. 2016 Jul 1;187:232-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB

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