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LDC4297

CAT: 0804-HY-12653-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12653-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDC4297 is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 value of 0.02-1.21 μM. LDC4297 can be used for the research of infection[1].
CAS Number
1453834-21-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; HIV; HSV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/LDC4297.html
Purity
98.14
Solubility
DMSO : ≥ 60 mg/mL
Smiles
CC(C)C1=C(N2N=C1)N=C(OC3CNCCC3)N=C2NCC4=CC=CC=C4N5C=CC=N5
Molecular Formula
C23H28N8O
Molecular Weight
432.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Hutterer C, et al. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2062-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK7; HSV-1; HSV-2

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