Clodronate (disodium tetrahydrate)
CAT:
804-HY-107794-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Clodronate (disodium tetrahydrate)
- CAS Number: 88416-50-6
- UNSPSC Description: Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Neurological Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/clodronate-disodium-tetrahydrate.html
- Purity: 98.0
- Solubility: H2O : 125 mg/mL (ultrasonic)
- Smiles: O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.O.O.O
- Molecular Weight: 360.92
- References & Citations: [1]Kato Y, et al. Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6297-E6305.|[2]Moriyama Y, et al. Clodronate: A Vesicular ATP Release Blocker. Trends Pharmacol Sci. 2018 Jan;39(1):13-23.Nat Neurosci. 2024 Jun 11.|Cell Rep Methods. 2023 Oct 23;3(10):100599.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched