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Decursin

CAT: 0804-HY-18981-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18981-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Decursin ((+) -Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities[1][2][3][4].
CAS Number
[5928-25-6]
Product Name Alternative
(+) -Decursin
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; CXCR; PKC
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; GPCR/G Protein; Immunology/Inflammation; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Decursin.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C/C(C)=C\C(O[C@H](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O
Molecular Formula
C19H20O5
Molecular Weight
328.36
Precautions
H302, H315, H319
References & Citations
[1]Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005 Feb 1;65 (3) :1035-44.|[2]Jung SY, et al. Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function. J Cell Biochem. 2012 May;113 (5) :1478-87. |[3]Son DB, et al. Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model. Cells. 2021 Mar 4;10 (3) :547.|[4]Ahn KS, et al. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 1996 Feb;62 (1) :7-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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Alternative Products

CatalogName
445934-01Decursin
A15699-1Decursin 1mg
A15699-5Decursin 5mg
A15699-100Decursin 100mg
A15699-500Decursin 500mg
A15699-50Decursin 50mg
A15699-10Decursin 10mg
A15699-25Decursin 25mg
A15699-10mM-DDecursin 10mM * 1mL in DMSO

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