Products for Research Use Only
RegisterLogin

SPD304

CAT: 0804-HY-111255-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-111255-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].
CAS Number
869998-49-2
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SPD304.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15
Molecular Formula
C32H32F3N3O2
Molecular Weight
547.61
References & Citations
[1]Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005.|[2]Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim) . 2014 Nov;347 (11) :798-805.|[3]Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7 (1) :3424.|[4]Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10 (3) :e0120713.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
M26461-01SPD304
T12985-01SPD304 dihydrochloride
A19364-25SPD304 25mg
A19364-10SPD304 10mg
A19364-50SPD304 50mg
A19364-5SPD304 5mg
A19364-1SPD304 1mg

Popular Products