4-Chlorocinnamic acid

• Description:

  4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) . 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial; Drug Derivative; Fungal; Tyrosinase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/4-chlorocinnamic-acid.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (O) /C=C/C1=CC=C (Cl) C=C1

• Molecular Formula:

  C9H7ClO2

• Molecular Weight:

  182.61

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297.|[2]Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242.|[3]Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6|[4]Cuan Y, et al. Anticonvulsant Activity of Halogen-Substituted Cinnamic Acid Derivatives and Their Effects on Glycosylation of PTZ-Induced Chronic Epilepsy in Mice. Molecules. 2017 Dec 29;23 (1) :76.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1615-02-7