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4-Chlorocinnamic acid

CAT: 0804-HY-Y0729-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0729-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Chlorocinnamic acid is a derivative of Cinnamic acid. 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4].
CAS Number
1615-02-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Drug Derivative; Fungal; Tyrosinase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-chlorocinnamic-acid.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC=C(Cl)C=C1
Molecular Formula
C9H7ClO2
Molecular Weight
182.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297.|[2]Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242.|[3]Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6|[4]Cuan Y, et al. Anticonvulsant Activity of Halogen-Substituted Cinnamic Acid Derivatives and Their Effects on Glycosylation of PTZ-Induced Chronic Epilepsy in Mice. Molecules. 2017 Dec 29;23 (1) :76.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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